Kcnip2tm1.1(cre)Uze
Targeted Allele Detail
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| Symbol: |
Kcnip2tm1.1(cre)Uze |
| Name: |
Kv channel-interacting protein 2; targeted mutation 1.1, University of Zurich |
| MGI ID: |
MGI:7427724 |
| Synonyms: |
Kcnip2roxCre |
| Gene: |
Kcnip2 Location: Chr19:45780785-45804948 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband D1
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| Alliance: |
Kcnip2tm1.1(cre)Uze page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:332594
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Conditional ready, Recombinase) |
| Mutation: |
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Insertion
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Kcnip2tm1.1(cre)Uze expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting construct incorporated the sequence of an optimized roxed-Cre recombinase sequence preceded by the sequence coding for a short self-cleaving peptide P2A, and followed by an FRT-flanked neomycin resistance gene (Neo) into the third coding exon of the Kcnip2 gene. The insert carries an intersectional Dre-dependent Cre recombinase sequence achieved through the inclusion of a STOP cassette flanked by a pair of rox sites into the cre sequence. In presence of dre recombinase, cre recombinase is expressed driven by Kcnip2. The neo-selection sequence was removed by crossing chimeric mice with Flpe deleter mice.
(J:332594)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Kcnip2
(mouse)
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| Original: |
J:332594 Albisetti GW, et al., Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold. Neuron. 2023 Jan 4;111(1):92-105.e5 |
| All: |
1 reference(s) |
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