Tg(CDX2-cre/ERT2)741Erf
Transgene Detail
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| Symbol: |
Tg(CDX2-cre/ERT2)741Erf |
| Name: |
transgene insertion 741, Eric Fearon |
| MGI ID: |
MGI:7433054 |
| Synonyms: |
CDX2-creERT2 |
| Transgene: |
Tg(CDX2-cre/ERT2)741Erf Location: unknown
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| Alliance: |
Tg(CDX2-cre/ERT2)741Erf page
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| Strain of Origin: |
C57BL/6J x SJL/J
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(CDX2-cre/ERT2)741Erf expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| human |
CDX2 (1045) |
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Mutation details: The transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain), and a bovine growth hormone polyadenylation cassette. Compared to the CDX2P-CreER T2 transgenic line #752, transgenic line #741 shows increased tamoxifen-regulated Cre function in distal colon epithelium.
(J:199069)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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CDX2
(human)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:199069 Feng Y, et al., Sox9 induction, ectopic paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic apc inactivation. Am J Pathol. 2013 Aug;183(2):493-503 |
| All: |
4 reference(s) |
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Analysis Tools
