Htr6<tm1.1(cre)Smoc> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7435295)

Htr6^{tm1.1(cre)Smoc}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Htr6^{tm1.1(cre)Smoc}
Name:	5-hydroxytryptamine (serotonin) receptor 6; targeted mutation 1.1, Shanghai Model Organisms Center
MGI ID:	MGI:7435295
Synonyms:	5 HT6R^-
Gene:	Htr6 Location: Chr4:138788419-138802881 bp, - strand Genetic Position: Chr4, 70.57 cM
Alliance:	Htr6^{tm1.1(cre)Smoc} page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Null/knockout, Recombinase, Reporter)

Mutation:

Insertion

Htr6^{tm1.1(cre)Smoc} expression driven by 1 gene

Mutation details: A creERT2-P2A-EGFP-SV40PA expression cassette was inserted at exon 2 of the Htr6 gene via homologous recombination. The germline insertion disrupted locus. Western blot analysis of 5-HT6R confirmed that the null mutant. (J:333280)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Htr6 (mouse) Summary of all recombinase alleles driven by Htr6. Alliance mouse Htr6 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Htr6 Mutation:	27 strains or lines available

References

Original:	J:333280 Sun Z, et al., 5-HT6R null mutatrion induces synaptic and cognitive defects. Aging Cell. 2021 Jun;20(6):e13369
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/02/2024 MGI 6.13