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Htr6tm1.1(cre)Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Htr6tm1.1(cre)Smoc
Name: 5-hydroxytryptamine (serotonin) receptor 6; targeted mutation 1.1, Shanghai Model Organisms Center
MGI ID: MGI:7435295
Synonyms: 5 HT6R-
Gene: Htr6  Location: Chr4:138788419-138802881 bp, - strand  Genetic Position: Chr4, 70.57 cM
Alliance: Htr6tm1.1(cre)Smoc page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Htr6tm1.1(cre)Smoc expression driven by 1 gene
 
Mutation details: A creERT2-P2A-EGFP-SV40PA expression cassette was inserted at exon 2 of the Htr6 gene via homologous recombination. The germline insertion disrupted locus. Western blot analysis of 5-HT6R confirmed that the null mutant. (J:333280)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Htr6 (mouse)
Summary of all recombinase alleles driven by Htr6.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr6 Mutation:  27 strains or lines available
References
Original:  J:333280 Sun Z, et al., 5-HT6R null mutatrion induces synaptic and cognitive defects. Aging Cell. 2021 Jun;20(6):e13369
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory