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Spp1tm1.1(cre/ERT2)Jrs
Targeted Allele Detail
Summary
Symbol: Spp1tm1.1(cre/ERT2)Jrs
Name: secreted phosphoprotein 1; targeted mutation 1.1, Joshua R Sanes
MGI ID: MGI:7437681
Synonyms: OPN-, OPNCreER
Gene: Spp1  Location: Chr5:104582984-104588916 bp, + strand  Genetic Position: Chr5, 50.68 cM
Alliance: Spp1tm1.1(cre/ERT2)Jrs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:245845
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Spp1tm1.1(cre/ERT2)Jrs expression driven by 1 gene
 
Mutation details: The allele was generated by inserting CreER into the translation start codon of the Spp1 gene using lambda phage-mediated recombineering followed by homologous recombination in ES cells. Chimera mice were crossed to mice expressing FLP recombinase to remove the PGK-NEO cassette. (J:245845)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Spp1 (mouse)
Summary of all recombinase alleles driven by Spp1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spp1 Mutation:  43 strains or lines available
References
Original:  J:245845 Duan X, et al., Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015 Mar 18;85(6):1244-56
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory