About   Help   FAQ
Prdm1tm5.1(cre/ERT2)Rob
Targeted Allele Detail
Summary
Symbol: Prdm1tm5.1(cre/ERT2)Rob
Name: PR domain containing 1, with ZNF domain; targeted mutation 5.1, Elizabeth J Robertson
MGI ID: MGI:7438442
Synonyms: Prdm1CreERT2, Prdm1CreERT2-LacZ
Gene: Prdm1  Location: Chr10:44313173-44404497 bp, - strand  Genetic Position: Chr10, 23.24 cM
Alliance: Prdm1tm5.1(cre/ERT2)Rob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:257197
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Mutation:    Insertion
 
Prdm1tm5.1(cre/ERT2)Rob expression driven by 1 gene
 
Mutation details: The allele was generated by introducing a cassette containing a CreERT2 upstream of IRES-nlacZ followed by a FRT-flanked neo cassette (CreERT2-IRES-nLacZ-FRT-neo-FRT) into the ATG translational site in exon 3 of the Prdm1 gene via homologous recombination in embryonic stem (ES) cells. Correctly targeted ES cell clones were transiently transfected with a FLP expression construct to excise the neo cassette. (J:257197)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Prdm1 (mouse)
Summary of all recombinase alleles driven by Prdm1.
 

Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prdm1 Mutation:  66 strains or lines available
References
Original:  J:257197 Elias S, et al., Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life. Nat Commun. 2017 Nov 20;8(1):1714
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory