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Pdyntm1.1(cre/GFP)Rpa
Targeted Allele Detail
Summary
Symbol: Pdyntm1.1(cre/GFP)Rpa
Name: prodynorphin; targeted mutation 1.1, Richard D Palmiter
MGI ID: MGI:7439919
Gene: Pdyn  Location: Chr2:129528485-129541764 bp, - strand  Genetic Position: Chr2, 63.19 cM
Alliance: Pdyntm1.1(cre/GFP)Rpa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:331457
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Pdyntm1.1(cre/GFP)Rpa expression driven by 1 gene
 
Mutation details: A cassette encoding Cre:GFP (a Myc-tag and nuclear localization signals at the N-terminus of Cre recombinase, which is fused to green fluorescent protein followed by a SV40 polyadenylation sequence) was inserted just 5' of the initiation codon in the first coding exon of the Pdyn gene via homologous recombination. The neomycin cassette was excised of through crosses with animals broadly expressing Flp recombinase. (J:331457)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdyn (mouse)
Summary of all recombinase alleles driven by Pdyn.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdyn Mutation:  20 strains or lines available
References
Original:  J:331457 Pauli JL, et al., Molecular and anatomical characterization of parabrachial neurons and their axonal projections. Elife. 2022 Nov 1;11
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory