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Rorcem1.1(cre/ERT2)Ayr
Endonuclease-mediated Allele Detail
Summary
Symbol: Rorcem1.1(cre/ERT2)Ayr
Name: RAR-related orphan receptor gamma; endonuclease-mediated mutation 1.1, Alexander Y Rudensky
MGI ID: MGI:7442010
Synonyms: RorcVenus-T2A-creERT2
Gene: Rorc  Location: Chr3:94280106-94305583 bp, + strand  Genetic Position: Chr3, 40.56 cM, cytoband F2
Alliance: Rorcem1.1(cre/ERT2)Ayr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:333738
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Rorcem1.1(cre/ERT2)Ayr expression driven by 1 gene
 
Mutation details: The IRES-Venus-T2A-creER-frt-NeoR-frt cassette was inserted into the Rorc 3-UTR in embryonic stem (ES) cells using the CRISPR/Cas9 system. The resulting chimeras were bred with FLPeR mice to excise the NEO cassette. (J:333738)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Rorc (mouse)
Summary of all recombinase alleles driven by Rorc.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rorc Mutation:  44 strains or lines available
References
Original:  J:333738 Akagbosu B, et al., Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota. Nature. 2022;610(7933):752-760
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory