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Il25tm2.1(icre)Lky
Targeted Allele Detail
Summary
Symbol: Il25tm2.1(icre)Lky
Name: interleukin 25; targeted mutation 2.1, Richard M Locksley
MGI ID: MGI:7442196
Synonyms: 25Cre
Gene: Il25  Location: Chr14:55170152-55173294 bp, + strand  Genetic Position: Chr14, 28.0 cM
Alliance: Il25tm2.1(icre)Lky page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:333765
Parent Cell Line:  PRX-B6T (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Il25tm2.1(icre)Lky expression driven by 1 gene
 
Mutation details: A humanized (eukaryotic codon-optimized) Cre and an FRT flanked neo cassette were inserted in the 3'UTR via homologous recombination. Flp mediated recombination removed the neo cassette. (J:333765)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Il25 (mouse)
Summary of all recombinase alleles driven by Il25.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il25 Mutation:  15 strains or lines available
References
Original:  J:333765 O'Leary CE, et al., Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 Mar 4;7(69):eabj1080
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory