Atoh1tm2.1(cre/ERT2,-CD2)Dwi
Targeted Allele Detail
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| Symbol: |
Atoh1tm2.1(cre/ERT2,-CD2)Dwi |
| Name: |
atonal bHLH transcription factor 1; targeted mutation 2.1, Douglas J Winton |
| MGI ID: |
MGI:7444368 |
| Synonyms: |
Atoh1(9S/T-A)CreERT2 |
| Gene: |
Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
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| Alliance: |
Atoh1tm2.1(cre/ERT2,-CD2)Dwi page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:271399
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Dominant negative, Epitope tag, Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutations: |
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Insertion, Intergenic deletion
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Atoh1tm2.1(cre/ERT2,-CD2)Dwi expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Atoh1 (MGI:104654) |
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Mutation details: The targeting construct was designed to introduce a loxP site into 5'UTR of Atoh1, followed by the hyperactive phosphomutant (9 amino acids S/T to A changes) Atoh1 sequence Atoh1(9S/T-A) merged to the P2A-CreERT2-hCD2 then to a neomycin cassette inserted such that the 3'UTR was not disrupted. Following successful germline transmission, the mice heterozygous for the targeting construct were crossed onto PGK-Cre line in order to remove both the neo-selection cassette and the endogenous Atoh1 locus at the same time.
(J:271399)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Atoh1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Atoh1 Mutation: |
37 strains or lines available
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| Original: |
J:271399 Tomic G, et al., Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. Cell Stem Cell. 2018 Sep 6;23(3):436-443.e7 |
| All: |
1 reference(s) |
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Analysis Tools
