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Flt3lem1(cre/ERT2)Bcgen
Endonuclease-mediated Allele Detail
Summary
Symbol: Flt3lem1(cre/ERT2)Bcgen
Name: FMS-like tyrosine kinase 3 ligand; endonuclease-mediated mutation 1, Biocytogen LLC
MGI ID: MGI:7444377
Synonyms: Flt3l-reporter
Gene: Flt3l  Location: Chr7:44780607-44785914 bp, - strand  Genetic Position: Chr7, 29.14 cM, cytoband B2-C
Alliance: Flt3lem1(cre/ERT2)Bcgen page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase, Reporter)
Mutation:    Insertion
 
Flt3lem1(cre/ERT2)Bcgen expression driven by 1 gene
 
Mutation details: A P2A-iCreERT2-T2A-TFP sequence was inserted between exon 8 and the 3 -UTR of Flt3l at the endogenous locus using CRISPRCas9 targeting. (J:271622)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Flt3l (mouse)
Summary of all recombinase alleles driven by Flt3l.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flt3l Mutation:  14 strains or lines available
References
Original:  J:271622 Barry KC, et al., A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018 Aug;24(8):1178-1191
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory