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Sim1tm1.1(cre)Lowl
Targeted Allele Detail
Summary
Symbol: Sim1tm1.1(cre)Lowl
Name: single-minded family bHLH transcription factor 1; targeted mutation 1.1, Bradford B Lowell
MGI ID: MGI:7444470
Synonyms: Sim1-IRES-Cre
Gene: Sim1  Location: Chr10:50770850-50865248 bp, + strand  Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
Alliance: Sim1tm1.1(cre)Lowl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:276251
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Sim1tm1.1(cre)Lowl expression driven by 1 gene
 
Mutation details: A selection cassette containing an internal ribosomal entry sequence (IRES) linked to Cre-recombinase and an Frt-flanked neomycin resistance gene was targeted 3 bp after the stop codon of the Sim1 gene, so that Cre-recombinase expression was driven by the endogenous gene. Flpe recombinase transgene mice were then used to remove the neomycin selection cassette. (J:276251)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sim1 (mouse)
Summary of all recombinase alleles driven by Sim1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sim1 Mutation:  52 strains or lines available
References
Original:  J:276251 Li MM, et al., The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Neuron. 2019 May 8;102(3):653-667.e6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory