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Uri1tm2.1(cre/ERT2)Ndj
Targeted Allele Detail
Summary
Symbol: Uri1tm2.1(cre/ERT2)Ndj
Name: URI1, prefoldin-like chaperone; targeted mutation 2.1, Nabil Djouder
MGI ID: MGI:7444769
Synonyms: URICreERT2, URI-creERT2-IRES-EGFP
Gene: Uri1  Location: Chr7:37659417-37722976 bp, - strand  Genetic Position: Chr7, 25.29 cM
Alliance: Uri1tm2.1(cre/ERT2)Ndj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277739
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Uri1tm2.1(cre/ERT2)Ndj expression driven by 1 gene
 
Mutation detailsA creERT2-IRES-EGFP cassette was inserted immediately after the promoter in exon 1 of the Uri1 gene. The founder mouse was obtained by crossing the chimera to the strain carrying FLPe-recombinase to remove the kanamycin/neomycin cassette. (J:277739)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Uri1 (mouse)
Summary of all recombinase alleles driven by Uri1.
 

Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Uri1 Mutation:  72 strains or lines available
References
Original:  J:277739 Chaves-Perez A, et al., URI is required to maintain intestinal architecture during ionizing radiation. Science. 2019 May 31;364(6443)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory