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Ptf1atm1(flpo)Hcrd
Targeted Allele Detail
Summary
Symbol: Ptf1atm1(flpo)Hcrd
Name: pancreas specific transcription factor, 1a; targeted mutation 1, Howard C Crawford
MGI ID: MGI:7447045
Synonyms: Ptf1aFlpO
Gene: Ptf1a  Location: Chr2:19450474-19452312 bp, + strand  Genetic Position: Chr2, 13.37 cM, cytoband A2
Alliance: Ptf1atm1(flpo)Hcrd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:294489
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Ptf1atm1(flpo)Hcrd expression driven by 1 gene
 
Mutation details: The entire coding region was replaced with a cassette containing Flpo recombinase and Frt flanked hygromycin resistance gene by RMCE using Ptf1atm1Mgn. The Frt flanked hygromycin resistance cassette was removed by self-excision via flp recombinase. (J:294489)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ptf1a (mouse)
Summary of all recombinase alleles driven by Ptf1a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptf1a Mutation:  31 strains or lines available
References
Original:  J:294489 Wen HJ, et al., Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;8(2):173-192
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory