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Lyz1tm2.1(cre/ERT2)Cle
Targeted Allele Detail
Summary
Symbol: Lyz1tm2.1(cre/ERT2)Cle
Name: lysozyme 1; targeted mutation 2.1 Hans Clevers
MGI ID: MGI:7447075
Synonyms: pLys-CreErt2
Gene: Lyz1  Location: Chr10:117123702-117128773 bp, - strand  Genetic Position: Chr10, 65.35 cM
Alliance: Lyz1tm2.1(cre/ERT2)Cle page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:285915
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Mutation:    Insertion
 
Lyz1tm2.1(cre/ERT2)Cle expression driven by 1 gene
 
Mutation details: A Cre/ERT2 gene was inserted onto the ATG of the Lyz1 gene through homologous recombination in ES cells. The neomycin selection cassette was flanked by Frt recombination sites and excised in vivo by crossing the mice with the general FLP deleter strain. (J:285915)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lyz1 (mouse)
Summary of all recombinase alleles driven by Lyz1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lyz1 Mutation:  15 strains or lines available
References
Original:  J:285915 van Es JH, et al., Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion. Proc Natl Acad Sci U S A. 2019 Dec 16;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory