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Mc4rem2(cre)Vai
Endonuclease-mediated Allele Detail
Summary
Symbol: Mc4rem2(cre)Vai
Name: melanocortin 4 receptor; endonuclease-mediated mutation 2, Christian Vaisse
MGI ID: MGI:7447190
Synonyms: MC4Rt2aCre, Mc4rtm2(t2a Cre)Vai
Gene: Mc4r  Location: Chr18:66990776-66993558 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Alliance: Mc4rem2(cre)Vai page
Mutation
origin
Strain of Origin:  FVB/N
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Mc4rem2(cre)Vai expression driven by 1 gene
 
Mutation details: A t2a-Cre sequence was inserted in-frame immediately downstream of following the Mc4r stop codon by CRISPR-Cas9. (J:334174)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mc4r (mouse)
Summary of all recombinase alleles driven by Mc4r.
 

Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:  48 strains or lines available
References
Original:  J:334174 Wang Y, et al., Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. J Clin Invest. 2021 May 3;131(9)
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory