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Ascl3tm2.1(icre/ESR1*)Ovi
Targeted Allele Detail
Summary
Symbol: Ascl3tm2.1(icre/ESR1*)Ovi
Name: achaete-scute family bHLH transcription factor 3; targeted mutation 2.1, Catherine E Ovitt
MGI ID: MGI:7447443
Gene: Ascl3  Location: Chr7:109326672-109330933 bp, - strand  Genetic Position: Chr7, 57.46 cM
Alliance: Ascl3tm2.1(icre/ESR1*)Ovi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ascl3tm2.1(icre/ESR1*)Ovi expression driven by 1 gene
 
Mutation details: The targeting vector consists of a P2A sequence followed by an icre (codon-optimized cre) /mutated human ESR1 fusion protein and an FRT-flanked PGK-neomycin selection cassette. The targeting construct was inserted immediately upstream of the termination codon of the achaete-scute family bHLH transcription factor 3 (Ascl3) gene. The neo-selection cassette was removed by Flp recombinase. (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ascl3 (mouse)
Summary of all recombinase alleles driven by Ascl3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ascl3 Mutation:  9 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory