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Mki67em1(cre/ERT2)Bzsh
Endonuclease-mediated Allele Detail
Summary
Symbol: Mki67em1(cre/ERT2)Bzsh
Name: antigen identified by monoclonal antibody Ki 67; endonuclease-mediated mutation 1, Bin Zhou
MGI ID: MGI:7451128
Synonyms: Ki67-CrexER
Gene: Mki67  Location: Chr7:135291513-135318090 bp, - strand  Genetic Position: Chr7, 81.32 cM, cytoband F3-F5
Alliance: Mki67em1(cre/ERT2)Bzsh page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mki67em1(cre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technolgy, the CrexER (Cre-rox-ER-rox) was generated by the insertion of two rox sequences flanking ERT2, a cDNA encoding CrexER recombinase replaced the translational stop codon of the Mki67 gene, following endogenous Mki67 by the self-cleaving peptide 2A sequence. (J:303771, J:339117)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mki67 (mouse)
Summary of all recombinase alleles driven by Mki67.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mki67 Mutation:  146 strains or lines available
References
Original:  J:303771 He L, et al., Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science. 2021 Feb 26;371(6532)
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory