Glul<em2(cre/ERT2)Bzsh> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7451132)

Glul^{em2(cre/ERT2)Bzsh}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Glul^{em2(cre/ERT2)Bzsh}
Name:	glutamate-ammonia ligase; endonuclease-mediated mutation 2, Bin Zhou
MGI ID:	MGI:7451132
Synonyms:	GS-CreER
Gene:	Glul Location: Chr1:153775692-153785469 bp, + strand Genetic Position: Chr1, 65.43 cM, cytoband G2
Alliance:	Glul^{em2(cre/ERT2)Bzsh} page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Glul^{em2(cre/ERT2)Bzsh} expression driven by 1 gene

Mutation details: Using CRISPR/Cas9 technology, the CreERT2 cassette was inserted into the translational stop codon of the Glul gene, following endogenous Glul by the self-cleaving peptide 2A sequence. (J:303771)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Glul (mouse) Summary of all recombinase alleles driven by Glul. Alliance mouse Glul gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Glul Mutation:	33 strains or lines available

References

Original:	J:303771 He L, et al., Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science. 2021 Feb 26;371(6532)
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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