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Npr3em2(scre/ERT2)Bzsh
Endonuclease-mediated Allele Detail
Summary
Symbol: Npr3em2(scre/ERT2)Bzsh
Name: natriuretic peptide receptor 3; endonuclease-mediated mutation 2, Bin Zhou
MGI ID: MGI:7451372
Synonyms: Npr3-sCreER
Gene: Npr3  Location: Chr15:11839982-11907287 bp, - strand  Genetic Position: Chr15, 5.83 cM
Alliance: Npr3em2(scre/ERT2)Bzsh page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Npr3em2(scre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: Using the CRISPR/Cas9 technology, a cDNA encoding sCre (self-cleaving cre) fused to ERT2 followed by the Woodchuck Post-transcriptional regulatory element and a polyadenylation sequence was inserted in frame with the translational start codon of the Npr3 gene. (J:309164)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Npr3 (mouse)
Summary of all recombinase alleles driven by Npr3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr3 Mutation:  49 strains or lines available
References
Original:  J:309164 Tian X, et al., Generation of a self-cleaved inducible Cre recombinase for efficient temporal genetic manipulation. EMBO J. 2020 Feb 17;39(4):e102675
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory