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Col1a2em2(scre/ERT2)Bzsh
Endonuclease-mediated Allele Detail
Summary
Symbol: Col1a2em2(scre/ERT2)Bzsh
Name: collagen, type I, alpha 2; endonuclease-mediated mutation 2, Bin Zhou
MGI ID: MGI:7451373
Synonyms: Col1a2-sCreER
Gene: Col1a2  Location: Chr6:4505618-4541543 bp, + strand  Genetic Position: Chr6, 1.81 cM
Alliance: Col1a2em2(scre/ERT2)Bzsh page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Col1a2em2(scre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: Using the CRISPR/Cas9 technology, a cDNA encoding sCre (self-cleaving cre) fused to ERT2 followed by the Woodchuck Post-transcriptional regulatory element and a polyadenylation sequence was inserted in frame with the translational start codon of the Col1a2 gene. (J:309164)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Col1a2 (mouse)
Summary of all recombinase alleles driven by Col1a2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a2 Mutation:  120 strains or lines available
References
Original:  J:309164 Tian X, et al., Generation of a self-cleaved inducible Cre recombinase for efficient temporal genetic manipulation. EMBO J. 2020 Feb 17;39(4):e102675
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory