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Ascl1tm1(Ccre)Cschu
Targeted Allele Detail
Summary
Symbol: Ascl1tm1(Ccre)Cschu
Name: achaete-scute family bHLH transcription factor 1; targeted mutation 1, Carol Schuurmans
MGI ID: MGI:7451387
Synonyms: Ascl1C-CreKI
Gene: Ascl1  Location: Chr10:87326681-87329522 bp, - strand  Genetic Position: Chr10, 43.64 cM
Alliance: Ascl1tm1(Ccre)Cschu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:310880
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Ascl1tm1(Ccre)Cschu expression driven by 1 gene
 
Mutation details: A targeting vector replaced the genomic sequence between the Ascl1 START and STOP codon with C-Cre (amino acids 60-343 in Ascl1 locus) modified with a nuclear-localization signal, GCN4 coiled-coil domain, flexible linker, and partial Cre-recombinase sequences. (J:310880)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ascl1 (mouse)
Summary of all recombinase alleles driven by Ascl1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ascl1 Mutation:  28 strains or lines available
References
Original:  J:310880 Han S, et al., Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding. Neuron. 2021 Sep 15;109(18):2847-2863.e11
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory