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Lgr5em1(cre/ERT2)Kba
Endonuclease-mediated Allele Detail
Summary
Symbol: Lgr5em1(cre/ERT2)Kba
Name: leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 1, Konrad Basler
MGI ID: MGI:7460264
Synonyms: Lgr5-2A-CreERT2-2A-mOrange2, Lgr5ZH
Gene: Lgr5  Location: Chr10:115286219-115423685 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance: Lgr5em1(cre/ERT2)Kba page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lgr5em1(cre/ERT2)Kba expression driven by 1 gene
 
Mutation details: CRISPR-targeting introduced a sequence containing an Lgr5-2A-CreERT2-2A-mOrange2 at the 3 end of the Lgr5 gene. (J:334516)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lgr5 (mouse)
Summary of all recombinase alleles driven by Lgr5.
 

Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr5 Mutation:  58 strains or lines available
References
Original:  J:334516 Reichmuth J, et al., Manipulating the murine Lgr5 locus using a rapid, efficient and flexible CRISPR/Cas9 pipeline. bioRxiv. 2020;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory