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Scn10aem1(dre)Fens
Endonuclease-mediated Allele Detail
Summary
Symbol: Scn10aem1(dre)Fens
Name: sodium channel, voltage-gated, type X, alpha; endonuclease-mediated mutation 1, Henning Fenselau
MGI ID: MGI:7463971
Synonyms: Nav1.8-p2a-Dre
Gene: Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Alliance: Scn10aem1(dre)Fens page
Mutation
origin
Strain of Origin:  FVB
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Scn10aem1(dre)Fens expression driven by 1 gene
 
Mutation details: Using the CRISPR/Cas9 system, p2a-Dre was inserted just downstream of the stop codon (exon28) of the Scn10a gene. (J:314805)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Scn10a (mouse)
Summary of all recombinase alleles driven by Scn10a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:  102 strains or lines available
References
Original:  J:314805 Borgmann D, et al., Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 Jul 6;33(7):1466-1482.e7
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory