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Tnctm1(cre/ERT2)Gcr
Targeted Allele Detail
Summary
Symbol: Tnctm1(cre/ERT2)Gcr
Name: tenascin C; targeted mutation 1, Gerhard Christofori
MGI ID: MGI:7466158
Synonyms: Tnc-CreERT2, Tnctm1(cre/ERT2)Gcr
Gene: Tnc  Location: Chr4:63878022-63965252 bp, - strand  Genetic Position: Chr4, 34.06 cM
Alliance: Tnctm1(cre/ERT2)Gcr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:316041
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tnctm1(cre/ERT2)Gcr expression driven by 1 gene
 
Mutation details: Using ES cell electroporation and homologous recombination, a targeting vector encoding for Cre-ERT2-RPA (rabbit beta-globin gene polyadenylation signal) was targeted to the Tnc locus. (J:101977, J:316041)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tnc (mouse)
Summary of all recombinase alleles driven by Tnc.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnc Mutation:  135 strains or lines available
References
Original:  J:316041 Luond F, et al., Distinct contributions of partial and full EMT to breast cancer malignancy. Dev Cell. 2021 Nov 23;
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory