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Aldh1a1em2(cre)Ylu
Endonuclease-mediated Allele Detail
Summary
Symbol: Aldh1a1em2(cre)Ylu
Name: aldehyde dehydrogenase family 1, subfamily A1; endonuclease-mediated mutation 2, Youming Lu
MGI ID: MGI:7466201
Synonyms: Aldh1a1-/--CRE
Gene: Aldh1a1  Location: Chr19:20470079-20620829 bp, + strand  Genetic Position: Chr19, 13.91 cM
Alliance: Aldh1a1em2(cre)Ylu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Aldh1a1em2(cre)Ylu expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 system, P2A-CRE-pA was inserted downstream of exon 10 of the Aldh1a1 gene. The premature termination of the transcript deleted the exons 1113 corresponding to the 100 amino acids (401-500) of the C-terminal, which is essential for enzyme function and stability of Aldh1a1. It is a null allele. The absence of protein products was established by western blot analysis. (J:316743)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Aldh1a1 (mouse)
Summary of all recombinase alleles driven by Aldh1a1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aldh1a1 Mutation:  39 strains or lines available
References
Original:  J:316743 Li X, et al., Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors. Mol Neurodegener. 2021 Oct 26;16(1):73
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory