About   Help   FAQ
Dll4em1(cre/ERT2)Bz
Endonuclease-mediated Allele Detail
Summary
Symbol: Dll4em1(cre/ERT2)Bz
Name: delta like canonical Notch ligand 4; endonuclease-mediated mutation 1, Bin Zhou
MGI ID: MGI:7467077
Synonyms: Dll4creERT2
Gene: Dll4  Location: Chr2:119156286-119166145 bp, + strand  Genetic Position: Chr2, 59.97 cM, cytoband E3
Alliance: Dll4em1(cre/ERT2)Bz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:317975
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Dll4em1(cre/ERT2)Bz expression driven by 1 gene
 
Mutation details: The allele was generated by knocking in a 2A peptide-linked creERT2 cDNA immediately before the stop codon of the Dll4 gene by CRISPRCas9 targeting and homozygous recombination in R1 mouse embryonic stem cells. (J:317975)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dll4 (mouse)
Summary of all recombinase alleles driven by Dll4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dll4 Mutation:  27 strains or lines available
References
Original:  J:317975 Lu P, et al., Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling. Nat Cell Biol. 2021 Sep;23(9):967-977
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory