About   Help   FAQ
Axin2tm1.1(cre/ERT2)Niba
Targeted Allele Detail
Summary
Symbol: Axin2tm1.1(cre/ERT2)Niba
Name: axin 2; targeted mutation 1.1, Nick Barker
MGI ID: MGI:7468751
Synonyms: Axin2-2A-CreERT2
Gene: Axin2  Location: Chr11:108811175-108841609 bp, + strand  Genetic Position: Chr11, 71.83 cM
Alliance: Axin2tm1.1(cre/ERT2)Niba page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:319855
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Axin2tm1.1(cre/ERT2)Niba expression driven by 1 gene
 
Mutation details: Sequence for the 2A self-cleaving peptide, a cre-ERT2 fusion gene and a loxP site flanked neomycin resistance gene cassette were inserted immediately before the stop codon. The neo cassette was removed through subsequent cre-mediated recombination. This allele expresses the endogenous peptide and the inserted cre-ERT2 fusion peptide. (J:319855)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Axin2 (mouse)
Summary of all recombinase alleles driven by Axin2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Axin2 Mutation:  44 strains or lines available
References
Original:  J:319855 Tan SH, et al., A constant pool of Lgr5(+) intestinal stem cells is required for intestinal homeostasis. Cell Rep. 2021 Jan 26;34(4):108633
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory