Bcl11a<tm1.1(cre/ERT2)Khal> Targeted Allele Detail MGI Mouse (MGI:7468922)

Bcl11a^{tm1.1(cre/ERT2)Khal}
Targeted Allele Detail

Summary

Symbol:	Bcl11a^{tm1.1(cre/ERT2)Khal}
Name:	BCL11 transcription factor A; targeted mutation 1.1, Walid T Khaled
MGI ID:	MGI:7468922
Synonyms:	Bcl11a^CreERT2
Gene:	Bcl11a Location: Chr11:24028056-24124123 bp, + strand Genetic Position: Chr11, 14.41 cM
Alliance:	Bcl11a^{tm1.1(cre/ERT2)Khal} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:335215
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Bcl11a^{tm1.1(cre/ERT2)Khal} expression driven by 1 gene

Mutation details: The allele was generated by introducing an IRES-CreERT2-polyA-FRT-PGK-E7-Neo-polyA-FRT cassette into the 3UTR of Bcl11a locus by targeted homologous recombination in the ES cells. (J:335215)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Bcl11a (mouse) Summary of all recombinase alleles driven by Bcl11a. Comparative matrix view of recombinase activities Alliance mouse Bcl11a gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Bcl11a Mutation:	44 strains or lines available

References

Original:	J:335215 Pensa S, et al., The generation of a Bcl11a lineage tracing mouse model. bioRxiv. 2021 Jul;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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