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Mcoln3tm1.1(cre)Lrcb
Targeted Allele Detail
Summary
Symbol: Mcoln3tm1.1(cre)Lrcb
Name: mucolipin 3; targeted mutation 1.1, Christian Grimm
MGI ID: MGI:7469457
Synonyms: Trpml3IRES-Cre
Gene: Mcoln3  Location: Chr3:145823205-145847561 bp, + strand  Genetic Position: Chr3, 71.03 cM
Alliance: Mcoln3tm1.1(cre)Lrcb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:320955
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mcoln3tm1.1(cre)Lrcb expression driven by 1 gene
 
Mutation details: The IRES-Cre-PGK-Neomycin cassette was inserted at 5 bp after the stop codon in exon 12 of the Mcoln3 (Trpml3) gene. The resulting mice were crossed with FLP deleter mice to remove the neo cassette. (J:320955)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mcoln3 (mouse)
Summary of all recombinase alleles driven by Mcoln3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcoln3 Mutation:  35 strains or lines available
References
Original:  J:320955 Spix B, et al., Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nat Commun. 2022 Jan 14;13(1):318
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory