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Tbx3tm4(cre/Esr1*)Moon
Targeted Allele Detail
Summary
Symbol: Tbx3tm4(cre/Esr1*)Moon
Name: T-box 3; targeted mutation 4, Anne M Moon
MGI ID: MGI:7471384
Synonyms: tbx3mcm, Tbx3mcm
Gene: Tbx3  Location: Chr5:119808734-119822789 bp, + strand  Genetic Position: Chr5, 60.34 cM
Alliance: Tbx3tm4(cre/Esr1*)Moon page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232111
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tbx3tm4(cre/Esr1*)Moon expression driven by 1 gene
 
Mutation details: The targeting construct inserted an IRES sequence followed by the mER:Cre:mER cDNA encoding a fusion protein with two copies of the mouse estrogen receptor (mER) flanking Cre recombinase, and a Neomycin resistance (NeoR) selection cassette flanked by Frt recombination sites in the Tbx3 gene. (J:232111)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx3 (mouse)
Summary of all recombinase alleles driven by Tbx3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx3 Mutation:  49 strains or lines available
References
Original:  J:232111 Emechebe U, et al., T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife. 2016;5:e07897
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory