Tg(Camk2a-cre/ERT2/Hif1a)#Heh
Transgene Detail
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| Symbol: |
Tg(Camk2a-cre/ERT2/Hif1a)#Heh |
| Name: |
transgene insertion, Hannelore Ehrenreich |
| MGI ID: |
MGI:7481236 |
| Synonyms: |
CamkIIa-CreERT2-ODD |
| Transgene: |
Tg(Camk2a-cre/ERT2/Hif1a)#Heh Location: unknown
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| Alliance: |
Tg(Camk2a-cre/ERT2/Hif1a)#Heh page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen and hypoxia |
| Mutation: |
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Insertion
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Tg(Camk2a-cre/ERT2/Hif1a)#Heh expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Camk2a (MGI:88256) |
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Mutation details: The transgene containing the murine Camk2a promoter drives expression of the tamoxifen-inducible cre recombinase gene (cre/ERT2) fused with the oxygen-dependent degradation (ODD) domain of Hif1a. This transgene is responsive to hypoxia. Under normoxic conditions, the ODD is hydroxylated by prolylhydroxylases, which tag HIF-1 upon binding of Von Hippel-Lindau (VHL) protein for proteasomal degradation. Hypoxic conditions lead to the inactivation of these enzymes and thus stabilization of HIF-1, allowing it to accumulate in the nucleus and activate the transcription of its target genes. The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:322009)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Camk2a
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:322009 Butt UJ, et al., CaMKIIalpha Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge. Int J Mol Sci. 2021 Mar 20;22(6) |
| All: |
1 reference(s) |
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Analysis Tools
