About   Help   FAQ
Trhem1(dre)Lowl
Endonuclease-mediated Allele Detail
Summary
Symbol: Trhem1(dre)Lowl
Name: thyrotropin releasing hormone; endonuclease-mediated mutation 1,Bradford B Lowell
MGI ID: MGI:7482625
Synonyms: Trh-p2a-Dre
Gene: Trh  Location: Chr6:92219042-92221631 bp, - strand  Genetic Position: Chr6, 41.03 cM
Alliance: Trhem1(dre)Lowl page
Mutation
origin
Strain of Origin:  FVB
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Trhem1(dre)Lowl expression driven by 1 gene
 
Mutation details: Using the CRISPR/Cas9 system, the p2a-Dre recombinase cassette was inserted in front of the Trh stop codon TAA in the 2nd exon of the Trh gene. (J:335546)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Trh (mouse)
Summary of all recombinase alleles driven by Trh.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trh Mutation:  23 strains or lines available
References
Original:  J:335546 Grzelka K, et al., A synaptic amplifier of hunger for regaining body weight in the hypothalamus. Cell Metab. 2023 May 2;35(5):770-785.e5
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory