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Gas1em1(icre/ERT2)Nono
Endonuclease-mediated Allele Detail
Summary
Symbol: Gas1em1(icre/ERT2)Nono
Name: growth arrest specific 1; endonuclease-mediated mutation 1, Noriaki Ono
MGI ID: MGI:7484373
Synonyms: Gas1-creER
Gene: Gas1  Location: Chr13:60322219-60325179 bp, - strand  Genetic Position: Chr13, 31.92 cM, cytoband B3-C2
Alliance: Gas1em1(icre/ERT2)Nono page
Mutation
origin
Strain of Origin:  (C57BL/6J x SJL/J)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gas1em1(icre/ERT2)Nono expression driven by 1 gene
 
Mutation details: using CRISPR/Cas9 endonuclease-mediated genome editing, P2A-iCreERT2-bGH polyA sequences were inserted into the 3' UTR region of the growth arrest specific 1 (Gas1) gene on chromosome 13. (J:335639)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gas1 (mouse)
Summary of all recombinase alleles driven by Gas1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gas1 Mutation:  14 strains or lines available
References
Original:  J:335639 Matsushita Y, et al., Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis. Nat Commun. 2023 Apr 25;14(1):2383
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory