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Ly6atm1.1(cre/ERT2)Geno
Targeted Allele Detail
Summary
Symbol: Ly6atm1.1(cre/ERT2)Geno
Name: lymphocyte antigen 6 family member A; targeted mutation 1.1, Genoway
MGI ID: MGI:7484560
Synonyms: Sca-1-CreERT2, Sca-1(Ly6a)-CreERT2
Gene: Ly6a  Location: Chr15:74866726-74869880 bp, - strand  Genetic Position: Chr15, 34.29 cM
Alliance: Ly6atm1.1(cre/ERT2)Geno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:335791
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ly6atm1.1(cre/ERT2)Geno expression driven by 1 gene
 
Mutation details: A cDNA encoding CreERT2 coding sequence and frt sites flanked neomycin cassette was inserted in frame of the Ly6a ATG start sequence by homologous recombination in ES cells. The neo selection sequence was later deleted by applying Flp-frt based system. (J:335791)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ly6a (mouse)
Summary of all recombinase alleles driven by Ly6a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ly6a Mutation:  22 strains or lines available
References
Original:  J:335791 Ni Z, et al., Multilineage commitment of Sca-1(+) cells in reshaping vein grafts. Theranostics. 2023;13(7):2154-2175
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory