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Tpcn2tm1.1(cre)Lrcb
Targeted Allele Detail
Summary
Symbol: Tpcn2tm1.1(cre)Lrcb
Name: two pore segment channel 2; targeted mutation 1.1, Christian Grimm
MGI ID: MGI:7486452
Synonyms: TPC2-IRES-Cre
Gene: Tpcn2  Location: Chr7:144740261-144837748 bp, - strand  Genetic Position: Chr7, 89.02 cM
Alliance: Tpcn2tm1.1(cre)Lrcb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:329280
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Tpcn2tm1.1(cre)Lrcb expression driven by 1 gene
 
Mutation details: The IRES-Cre-FRT-pgk-Neo-FRT cassette was inserted at 5 bp after the stop codon in exon 25 of the Tpcn2 gene. The resulting mice were crossed with FLP deleter mice to remove the neo cassette. (J:329280)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tpcn2 (mouse)
Summary of all recombinase alleles driven by Tpcn2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpcn2 Mutation:  52 strains or lines available
References
Original:  J:329280 Scotto Rosato A, et al., TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease. EMBO Mol Med. 2022 Sep 7;14(9):e15377
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory