About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:213958 Lang RA, et al., p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis. Development. 2014 Aug;141(16):3177-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7486721
Gene symbol: Ctnnd1
Gene name: catenin delta 1
Antibody: Anti-p120 Catenin (610133)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 5C: embryonic day 10.5; Ctnnd1tm1Abre/Ctnnd1tm1Abre (more )
Structure Level Pattern Image Note
TS17: lens pit Present 5C Localized mostly to the zonula adherens and did not appear to strongly colocalize with Shroom3 in prominent actomyosin filaments that spanned the apical cortex.
Specimen 5D: embryonic day 10.5; Ctnnd1tm1Abre/Ctnnd1tm1Abre, Tfap2atm1(cre)Moon/Tfap2a+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: lens pit Absent 5D
Specimen 5E: embryonic day 10.5; Ctnnd1tm1Abre/Ctnnd1+, Shroom3Gt(ROSA53)Sor/Shroom3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: lens pit Present 5E Average peak intensity revealed a 27.4% decrease in lens cell junctions compared with control cells.
Specimen S2E/E': embryonic day 10.5; Ctnnd1tm1Abre/Ctnnd1+ (more )
Structure Level Pattern Image Note
TS17: eye mesenchyme Present S2E' , S2E
TS17: lens pit Present S2E' , S2E
Specimen S2F/F': embryonic day 10.5; Ctnnd1tm1Abre/Ctnnd1tm1Abre, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: eye mesenchyme Absent S2F' , S2F
TS17: lens pit Present S2F' , S2F
Specimen S3B: embryonic day 10.0 (more )
Note: Double labeled: green - Ctnnd1; red - Myh10 (assay MGI:7486716).
Structure Level Pattern Image Note
TS16: lens placode Present S3B merge , S3B right
Specimen S3D: embryonic day 10.0 (more )
Note: Double labeled: green - Ctnnd1; red - Shroom3 (assay MGI:7486722).
Structure Level Pattern Image Note
TS16: lens placode Present S3D merge , S3D right
Specimen S3E/F: embryonic day 10.5 (more )
Note: Double labeled: green - Ctnnd1; red - Shroom3 (assay MGI:7486722).
Structure Level Pattern Image Note
TS17: lens pit Present S3F merge , S3E merge , S3F right , S3E right Localized mostly to the zonula adherens and did not appear to strongly colocalize with Shroom3 in prominent actomyosin filaments that spanned the apical cortex.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory