Aldh1a3tm1(cre/ERT2)Dac
Targeted Allele Detail
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| Symbol: |
Aldh1a3tm1(cre/ERT2)Dac |
| Name: |
aldehyde dehydrogenase family 1, subfamily A3; targeted mutation 1, Domenico Accili |
| MGI ID: |
MGI:7488653 |
| Synonyms: |
Aldh1a3-Creert |
| Gene: |
Aldh1a3 Location: Chr7:66040640-66077225 bp, - strand Genetic Position: Chr7, 35.73 cM, cytoband C
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| Alliance: |
Aldh1a3tm1(cre/ERT2)Dac page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:336250
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129 x C57BL/6
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Aldh1a3tm1(cre/ERT2)Dac expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A targeting construct was designed to insert the coding sequence for tamoxifen-inducible Cre recombinase fused with ERT2 and frt-flanked neo selection cassette downstream of the stop sequence of the Aldh3a1 locus with a P2A self-cleaving peptide separating the Aldh3a1 and cre/ERT2 coding sequences. The chimeric female mice were bred with ACTB-Flpe male mice to remove the frt-flanked neo cassette.
(J:336250)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Aldh1a3
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Aldh1a3 Mutation: |
26 strains or lines available
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129B6 hybrid-derived ES cells used.
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| Original: |
J:336250 Son J, et al., Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of beta-cell failure. Nat Commun. 2023 Feb 2;14(1):558 |
| All: |
1 reference(s) |
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Analysis Tools
