Col10a1<tm1.1(cre)Lyng> Targeted Allele Detail MGI Mouse (MGI:7490046)

Col10a1^{tm1.1(cre)Lyng}
Targeted Allele Detail

Summary

Symbol:	Col10a1^{tm1.1(cre)Lyng}
Name:	collagen, type X, alpha 1; targeted mutation 1.1, Liu Yang
MGI ID:	MGI:7490046
Synonyms:	Col10a1-CreA
Gene:	Col10a1 Location: Chr10:34265977-34273081 bp, + strand Genetic Position: Chr10, 18.85 cM, cytoband B1-B3
Alliance:	Col10a1^{tm1.1(cre)Lyng} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:324690
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Col10a1^{tm1.1(cre)Lyng} expression driven by 1 gene

Mutation details: A cre recombinase gene and FRT-flanked neomycin resistance cassette were inserted at the translation initiation site in exon 2. Flp-mediated recombination removed the selection cassette as Col10a1^{tm2.1(cre)Ksec} line described in J:122054. The recombination only took place in lower hypertrophic zone (HZ), which was delayed compared with that of Col10a1^{tm2.1(cre)Ksec} line. (J:324690)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col10a1 (mouse) Summary of all recombinase alleles driven by Col10a1. Alliance mouse Col10a1 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col10a1 Mutation:	28 strains or lines available

References

Original:	J:324690 Wang H, et al., Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened. Matrix Biol. 2022 Apr 23;
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24