Tg(Lhx8-icre)1Kess
Transgene Detail
|
|
| Symbol: |
Tg(Lhx8-icre)1Kess |
| Name: |
transgene insertion 1, Nicoletta Kessaris |
| MGI ID: |
MGI:7490134 |
| Synonyms: |
Lhx7-Cre |
| Transgene: |
Tg(Lhx8-icre)1Kess Location: unknown
|
| Alliance: |
Tg(Lhx8-icre)1Kess page
|
|
| Strain of Origin: |
Not Specified
|
|
| Transgene Type: |
|
Transgenic (Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Tg(Lhx8-icre)1Kess expression driven by
1 gene
Transgene expression driven by:
|
| |
|
Mutation details: Homologous recombination in bacteria was used to modify a 214 Kb BAC RP23-379E17 containing 130 Kb upstream and 61 Kb downstream of the Lhx8 (Lhx7) gene. The codon-improved Cre recombinase (iCre) containing a nuclear localization signal was fused to the initiation codon of the genes using a PCR-based approach. This was followed by a Simian Virus 40 polyadenylation signal and a Kanamycin resistance cassette that was flanked by FRT sites for the selection of recombinant BACs. BAC recombination was designed to delete the remaining ATG-encoding exon together with 50-200 bp from the downstream intron. Mice were generated by pronuclear injection of the construct into fertilized oocytes. No line number is given.
(J:330767)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Lhx8
(mouse)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:330767 Magno L, et al., Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons. Commun Biol. 2022 Oct 27;5(1):1137 |
| All: |
1 reference(s) |
|
Analysis Tools
