Cyp3a11tm1(flpo)Jic
Targeted Allele Detail
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| Symbol: |
Cyp3a11tm1(flpo)Jic |
| Name: |
cytochrome P450, family 3, subfamily a, polypeptide 11; targeted mutation 1, Central Institute for Experimental Animals, Japan |
| MGI ID: |
MGI:7491810 |
| Synonyms: |
Cyp3a11tm1(Flpo) |
| Gene: |
Cyp3a11 Location: Chr5:145791417-145816664 bp, - strand Genetic Position: Chr5, 85.17 cM
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| Alliance: |
Cyp3a11tm1(flpo)Jic page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:336704
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Cyp3a11tm1(flpo)Jic expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Cyp3a11 (MGI:88609) |
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Mutation details: The Flpo recombinase gene and FRT flanked CAG-Hyg selection cassette were inserted at the first ATG site of the Cyp3a11 gene by targeted transgenesis with homologous recombination such that it is under the control of the Cyp3a11 promoter. The embryonic stem cells (ES) used were established from NOG mice and a clone a5363 bearing Portm1.1Jic was used.
(J:336704)
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| Inheritance: |
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Not Specified |
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Cyp3a11
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cyp3a11 Mutation: |
43 strains or lines available
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Embryonic stem cells (ES) were established from NOG mice and a clone a5363 was used to select a double-recombinant NOG-ES cell clone, a5647.
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| Original: |
J:336704 Uehara S, et al., Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism. Sci Rep. 2022 Sep 1;12(1):14907 |
| All: |
1 reference(s) |
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Analysis Tools
