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Gene Expression Data
Assay Details
Assay
Reference: J:280803 Ma J, et al., Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin. PLoS Biol. 2019 Oct;17(10):e3000461
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7494027
Gene symbol: Dip2a
Gene name: disco interacting protein 2 homolog A
Reporter: lacZ
Direct Detection
Results
Specimen S2A: postnatal day 56; Dip2aem#bYwz/Dip2a+ (more )
Note: Double labeled: green - Dip2a reporter; red - Bcl11b (assay MGI:7494030) and Cux1 (assay MGI:7494029).
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex cerebral cortex pyramidal neuron Present Regionally restricted S2A Merge (right) , S2A Merge (left) , S2A LacZ Expression in pyramidal neurons in external layer colocalized with Cux1 and in internal layer colocalized with Bcl11b.
Specimen S2B: postnatal day 56; Dip2aem#bYwz/Dip2a+ (more )
Note: Double labeled: green - Dip2a reporter; red - Camk2a (assay MGI:7494031) and Camk2b (assay MGI:7494032).
Structure Level Pattern Image Note
TS28: cerebral cortex Present Widespread S2B Merge , S2B LacZ Expression in CaMKII-expressing neurons throughtout cortex.
Specimen 1E (upper): postnatal day 56; Dip2aem#bYwz/Dip2a+ (more )
Note: Double labeled: green - Dip2a reporter; red - Camk2a (assay MGI:7494031) and Camk2b (assay MGI:7494032).
Structure Level Pattern Image Note
TS28: cerebral cortex Present Widespread 1E inset (upper) , 1E LacZ (upper) , 1E Merge (upper) Expression in CaMKII-expressing neurons throughtout cortex.
Specimen 1E (lower): postnatal day 56; Dip2aem#bYwz/Dip2a+ (more )
Note: g Double labeled: green - Dip2a; red - GABA.
Structure Level Pattern Image Note
TS28: cerebral cortex Present Regionally restricted 1E LacZ (lower) , 1E Merge (lower) , 1E inset (lower) Partial expression in GABA-expressing neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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