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Prox2em1(flpo)Cbm
Endonuclease-mediated Allele Detail
Summary
Symbol: Prox2em1(flpo)Cbm
Name: prospero homeobox 2; endonuclease-mediated mutation 1, Carmen Birchmeier
MGI ID: MGI:7506801
Synonyms: Prox2FlpO
Gene: Prox2  Location: Chr12:85133159-85157533 bp, - strand  Genetic Position: Chr12, 39.54 cM
Alliance: Prox2em1(flpo)Cbm page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Prox2em1(flpo)Cbm expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technology, a 1.5kb fragment containing the codon-optimized FLP recombinase (FlpO) and a bovine poly(A) sequence was inserted between the 5 UTR and 1st exon of the Prox2 gene by homology-directed repair. (J:337785)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Prox2 (mouse)
Summary of all recombinase alleles driven by Prox2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prox2 Mutation:  19 strains or lines available
References
Original:  J:337785 Lowenstein ED, et al., Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Neuron. 2023 May 10;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory