Tg(ACTA1-Lrp4)#Line
Transgene Detail
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Symbol: |
Tg(ACTA1-Lrp4)#Line |
Name: |
transgene insertion, Lin Mei |
MGI ID: |
MGI:7507170 |
Synonyms: |
HSA::LRP4-FLTg, LRP4-FLtg |
Transgene: |
Tg(ACTA1-Lrp4)#Line Location: unknown
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Alliance: |
Tg(ACTA1-Lrp4)#Line page
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Strain of Origin: |
Not Applicable
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Transgene Type: |
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Transgenic (Epitope tag, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(ACTA1-Lrp4)#Line expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Lrp4 (MGI:2442252) |
human promoter, N-terminal FLAG tag, mouse cDNA |
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Tg(ACTA1-Lrp4)#Line expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
ACTA1 (58) |
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Mutation details: The transgene contains the following elements: human skeletal muscle actin alpha 1 promoter, polyomavirus capsid protein gene VP1, signal peptide sequence, FLAG tag sequence in-frame with mouse low density lipoprotein receptor-related protein 4 cDNA sequence, IRES sequence, GFP reporter gene, and SV40 poly(A) signal sequences.
(J:266450)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:266450 Zhao K, et al., Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. J Neurosci. 2018 Oct 10;38(41):8860-8873 |
All: |
4 reference(s) |
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