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Rorbtm1(cre)Hze
Targeted Allele Detail
Summary
Symbol: Rorbtm1(cre)Hze
Name: RAR-related orphan receptor beta; targeted mutation 1, Hongkui Zeng
MGI ID: MGI:7509098
Synonyms: Rorb-IRES2-Cre-neo
Gene: Rorb  Location: Chr19:18907969-19088560 bp, - strand  Genetic Position: Chr19, 13.28 cM
Alliance: Rorbtm1(cre)Hze page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146821
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Rorbtm1(cre)Hze expression driven by 1 gene
 
Mutation details: The targeting vector contained, from 5' to 3', a partial Rorb sequence from intron 9 (with an frt3), a partial Rorb exon 10 sequence including the endogenous stop codon, an internal ribosome entry site 2 (IRES2) sequence, a Cre recombinase gene, a bovine growth hormone polyA sequence, an AttB site, a PGK promoter-Neomycin resistance gene-PGK polyA cassette, an frt5 site, an mRNA splice acceptor, the 3' portion of the hygromycin gene with SV40 late polyA signal, and an AttP site. This construct was electroporated into G4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. (J:146821, J:220523)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Rorb (mouse)
Summary of all recombinase alleles driven by Rorb.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rorb Mutation:  41 strains or lines available
References
Original:  J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory