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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7511559
Gene symbol: Mpp4
Gene name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Antibody: Anti-MPP4 (AK4)
Detection system: Secondary antibody coupled to Cy3
Results
Specimen S6G: postnatal month 3; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: red - Mpp4; green - Prkca (assay MGI:7511558).
Structure Level Pattern Image Note
TS28: retina outer plexiform layer Present Regionally restricted S6G Expression was detected in a continuous band at the outer plexiform layer.
TS28: retina external limiting lamina Present Regionally restricted S6G Expression was present at the synapses of photoreceptors, and at lower levels at the outer limiting membrane. Expression was detected in a continuous band at the outer limiting membrane.
Specimen S6H: postnatal month 3; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: red - Mpp4; green - Prkca (assay MGI:7511558).
Structure Level Pattern Image Note
TS28: retina outer plexiform layer Present S6H The mutant immunopositive outer plexiform layer was thinner and showed some disruptions compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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