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Myh11em2(cre/ERT2)Jifz
Endonuclease-mediated Allele Detail
Summary
Symbol: Myh11em2(cre/ERT2)Jifz
Name: myosin, heavy polypeptide 11, smooth muscle; endonuclease-mediated mutation 2, Jifeng Zhang
MGI ID: MGI:7512810
Synonyms: Myh11-CreERT2-P2A
Gene: Myh11  Location: Chr16:14012392-14109227 bp, - strand  Genetic Position: Chr16, 9.71 cM
Alliance: Myh11em2(cre/ERT2)Jifz page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Myh11em2(cre/ERT2)Jifz expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technology, a cre/ERT2-P2A sequence was inserted into the endogenous Myh11 gene immediately after the first codon ATG in exon 2. (J:338442)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myh11 (mouse)
Summary of all recombinase alleles driven by Myh11.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myh11 Mutation:  94 strains or lines available
References
Original:  J:338442 Zhao Y, et al., Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells. JCI Insight. 2023 Jul 24;8(14):e171661
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory