Nmutm1.1(cre)Debu
Targeted Allele Detail
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| Symbol: |
Nmutm1.1(cre)Debu |
| Name: |
neuromedin U; targeted mutation 1.1, Dimitri De Bundel |
| MGI ID: |
MGI:7512918 |
| Synonyms: |
Nmu-Cre, NmuCre-IRES-Nmu |
| Gene: |
Nmu Location: Chr5:76481342-76511624 bp, - strand Genetic Position: Chr5, 40.93 cM
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| Alliance: |
Nmutm1.1(cre)Debu page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:338487
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (No functional change, Recombinase) |
| Mutation: |
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Insertion
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Nmutm1.1(cre)Debu expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A targeting construct was designed to insert a Cre coding sequence, an IRES element, the coding sequence of NMU isoform 1, an hGHpolyA signal, and a neomycin cassette for positive selection, flanked by two flippase recognition target (FRT) sites in frame with exon 1 ATG of the Nmu gene on chromosome 5 maintaining the expression of the most prevalent isoform of the Nmu gene products. After homologous recombination in ES cells, resulting chimeras were crossed to Flp deleter mice to excise the neo-cassette.
(J:338487)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Nmu
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nmu Mutation: |
18 strains or lines available
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| Original: |
J:338487 Medrano M, et al., Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells. Open Biol. 2023 Jun;13(6):220353 |
| All: |
1 reference(s) |
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Analysis Tools
