Cdkn2aem1(flpo,HBEGF/mCherry)Jpmb
Endonuclease-mediated Allele Detail
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| Symbol: |
Cdkn2aem1(flpo,HBEGF/mCherry)Jpmb |
| Name: |
cyclin dependent kinase inhibitor 2A; endonuclease-mediated mutation 1, Juan Pedro Martinez-Barbera |
| MGI ID: |
MGI:7514135 |
| Synonyms: |
p16-FDR |
| Gene: |
Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
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| Alliance: |
Cdkn2aem1(flpo,HBEGF/mCherry)Jpmb page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:338213
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| Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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| Strain of Origin: |
129S/SvEv-Gpi1c
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| Allele Type: |
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Endonuclease-mediated (Inserted expressed sequence, Recombinase, Reporter) |
| Mutation: |
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Insertion
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Cdkn2aem1(flpo,HBEGF/mCherry)Jpmb expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Cdkn2a (MGI:104738) |
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Mutation details: Using CRISPR/Cas9 system, a bicistronic targeting vector containing a mammalian optimized flippase (FLP) recombinase along with a diphtheria toxin receptor (HBEGF) fused with a mCherry fluorescent reporter separated by P2A sequences was inserted after the Stop codon in the exon3 of the Cdkn2a in ES cells.
(J:338213)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Cdkn2a
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cdkn2a Mutation: |
67 strains or lines available
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| Original: |
J:338213 Haston S, et al., Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer. Cancer Cell. 2023 Jul 10;41(7):1242-1260.e6 |
| All: |
1 reference(s) |
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Analysis Tools
