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Nkx2-1tm1(cre/ERT2)Htng
Targeted Allele Detail
Summary
Symbol: Nkx2-1tm1(cre/ERT2)Htng
Name: NK2 homeobox 1; targeted mutation 1, Hiroki Taniguchi
MGI ID: MGI:7514968
Synonyms: Nkx2.1-2A-CreER
Gene: Nkx2-1  Location: Chr12:56578741-56583570 bp, - strand  Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
Alliance: Nkx2-1tm1(cre/ERT2)Htng page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:338678
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Nkx2-1tm1(cre/ERT2)Htng expression driven by 1 gene
 
Mutation details: A 2A-CreER cassette and an frt-Neo-frt cassette were inserted in frame immediately after an open reading frame of an Nkx2-1 gene by homologous recombination. (J:338678)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx2-1 (mouse)
Summary of all recombinase alleles driven by Nkx2-1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-1 Mutation:  24 strains or lines available
References
Original:  J:338678 Hayano Y, et al., IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype. Sci Adv. 2021 Jul;7(29)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
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