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Cd300cem1(icre,CD2)Cln
Endonuclease-mediated Allele Detail
Summary
Symbol: Cd300cem1(icre,CD2)Cln
Name: CD300C molecule; endonuclease-mediated mutation 1, Marco Colonna
MGI ID: MGI:7520352
Synonyms: CD300cicre-hCD2
Gene: Cd300c  Location: Chr11:114846931-114851333 bp, - strand  Genetic Position: Chr11, 80.56 cM
Alliance: Cd300cem1(icre,CD2)Cln page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inserted expressed sequence, Recombinase)
Mutation:    Insertion
 
Cd300cem1(icre,CD2)Cln expresses 1 gene
 
Cd300cem1(icre,CD2)Cln expression driven by 1 gene
 
Mutation details: the IRES-iCre-P2A-hCD2 construct was inserted after the endogenous Cd300c STOP codon using CRISPR/Cas9 technology. (J:339120)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cd300c (mouse)
Summary of all recombinase alleles driven by Cd300c.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd300c Mutation:  13 strains or lines available
References
Original:  J:339120 Rodrigues PF, et al., pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells. Sci Immunol. 2023 Feb 24;8(80):eadd4132
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory